Abstract
Purpose: To evaluate in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) outcome in women with genital tuberculosis (GTB).
Methods: One hundred and fifty-five women with genital tuberculosis constituted the study group (Group A), consisting of 25 patients with endometrial tuberculosis (Group A1) and 130 patients with tubal tuberculosis (Group A2). Women with non-tuberculous tubal infertility were matched by age and study period served as controls (Group B).
Results: Patients with GTB had significantly reduced endometrial thickness, high-quality embryos rate, implantation rate as compared with controls (p < .05), no differences were found in other pregnancy parameters. In addition, the endometrial thickness, fertilization rate, high-quality embryos rate and implantation rate were also significantly lower in women with endometrial tuberculosis as compared with controls. And the cumulative pregnancy rate in endometrial tuberculosis was significantly decreased compared with tubal tuberculosis and controls (p < .05). However, IVF/ICSI pregnancy outcomes in patients with tubal tuberculosis showed no difference as compared with controls (p > .05). Also, rates of miscarriage, preterm birth, obstetrical complications, and neonatal problems did not differ among three groups.
Conclusions: In conclusion, IVF/ICSI-ET remains the most optimal method for the treatment of female infertility associated with tubal tuberculosis. However, patients with endometrium tuberculosis showed significantly reduced fertilization, implantation and cumulative pregnancy rates.
摘要
目的:评估体外受精(IVF)和胞浆内精子注射(ICSI)治疗生殖器结核(GTB)的效果。
方法:152例女性生殖器结核患者组成研究组(A组), 其中25例子宫内膜结核患者(A1组)和130例输卵管结核患者(A2组)。非结核性输卵管不育症的妇女按年龄和匹配的研究周期作为对照组(B组)。
结果:与对照组相比, GTB患者子宫内膜厚度、高质量胚胎率、着床率明显降低(p<.05), 其他妊娠指标无差异。此外, 子宫内膜结核患者的子宫内膜厚度、受精率、高质量胚胎率和着床率也明显低于对照组。子宫内膜结核患者和输卵管结核患者与对照组相比, 累积妊娠率明显降低(p<.05)。然而, 输卵管结核患者与对照组的IVF/ICSI妊娠结局无明显差异(p>.05)。三组的流产、早产、产科并发症及新生儿问题发生率没有差异。
结论:综上所述, IVF/ICSI-ET是治疗输卵管结核性不孕的最佳方法。然而, 子宫内膜结核患者的受精、着床和累积妊娠率显著降低。
The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.
Disclosure statement
No potential conflict of interest was reported by the authors.