Pituitary adenoma and apoplexy during GnRH agonist treatment for IVF - case report

Abstract

In vitro fertilization is commonly used for treating infertility. One stage of this process is controlled hyperstimulation of the ovaries, achieved by administering gonadotropins. There are several stimulation protocols utilized that increase the number of ovarian follicles during IVF. The most common protocol employs desensitization - the inhibition of follicle-stimulating hormone and luteinizing hormone secretion by the pituitary gland. This is achieved by administering a gonadotropin-releasing hormone (GnRH) analog that is agonistic for the GnRH receptor. However the use of a this drug during therapy carries a risk of complications. This case report deals with a rare case of a woman who underwent pituitary tumor growth as a result of the treatment of GnRH analog.

摘要

体外受精是常用治疗不孕症的手段。这个治疗中的一个阶段是通过注射促性腺激素来控制卵巢的过度刺激。在IVF过程中, 有几种刺激方案可以增加卵泡的数量。最常见的治疗方案是脱敏作用—即抑制垂体分泌卵泡刺激素和黄体生成素。这可以通过应用促性腺激素释放激素(GnRH)类似物激活GnRH受体来实现。然而, 在治疗过程中应用这种药物会有产生并发症的风险。本文报告了一例罕见病例, 一名女性由于应用GnRH类似物的治疗而发生了垂体肿瘤的生长。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• In vitro fertilization
• GnRH analogs
• gonadotropinoma
• stroke of the pituitary gland

Patient consent

Informed consent has been obtained from the patient (or patient’s guardian) for publication of the case report and accompanying images.

Disclosure statement

All authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.