Multicentric adrenocorticotropic hormone -producing steroid cell tumor of the fallopian tube & broad ligament in a 15 year old girl

Abstract

Steroid cell tumors occur usually in the ovaries with very few reported cases of extra-ovarian origin. Our patient was a fifteen year old female, complaining from secondary amenorrhea and voice deepening. Values of serum cortisol, DHEA, FSH & LH were normal. Serum Testosterone was elevated while ACTH-pm was markedly elevated. MRI described bilateral solid para-ovarian masses. Exploration revealed two bilateral tubal extraluminal cysts & a right broad ligament cyst which were all excised. Pathological examination led to the diagnosis of steroid cell tumor. Serum testosterone & ACTH returned to normal levels after surgery with subsequent regression of the virilizing symptoms. We can conclude that extra-ovarian steroid cell tumors are extremely rare. They are usually presented with virilizing symptoms and hormonal abnormalities. Surgery is the main line of treatment.

摘要

类固醇细胞肿瘤通常发生在卵巢中, 很少报道卵巢外起源的病例。该患者为15岁女性, 主诉继发性闭经和声音变粗, 血清皮质醇, DHEA, FSH和LH值正常。血清睾酮水平升高, ACTH-pm显着升高。MRI显示双侧卵巢实性肿物。探查发现两个双侧输卵管囊肿和一个右阔韧带囊肿, 均予切除。病理诊断为类固醇细胞瘤。手术后, 患者血清睾酮和促肾上腺皮质激素水平恢复到正常水平, 随后男性化症状消失。由此, 卵巢外类固醇细胞瘤极为罕见。通常表现为男性化症状和激素水平异常, 手术是治疗的主要手段。

The Chinese abstracts are translated by Prof. Dr. Xiangyan Ruan and her team: Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

Keywords:

• Virilism
• amenorrhea
• fallopian tube neoplasms
• cushing

Disclosure statement

No potential conflict of interest was reported by the author(s).

Availability of data and materials

All the clinical, radiological & pathological data used in this manuscript is available on Mansoura University database medical system (Ibn Sina Hospital management system). http://srv137.mans.edu.eg/mus/newSystem/.