Day 3 time lapse selection is beneficial for the patients with no good-quality embryos

Abstract

We aimed to evaluate whether or not time lapse selection was beneficial for the cleavage-stage embryo transfers. The study included 838 infertile women with good ovarian reserve (obtaining more than 8 oocytes) from January 2018 to August 2019. Based on the transferred embryos with different grades (grade I, II and III), the patients were divided into day 3 selection with conventional morphology (CM) and day 3 selection with time lapse (TL) groups. For the grade I and II embryos, we observed that CM and TL had similar implantation, clinical pregnancy and ongoing pregnancy (p > .05) rates. For the grade III embryos, we observed that CM group showed slightly lower implantation (36.74 versus 41.03%, p = .261) and clinical pregnancy (56.82 versus 64.10%, p = .182) rates than TL group. CM group showed significantly lower ongoing pregnancy (47.35 versus 59.83%, p = .025) rate than TL group. And we observed that CM group had significantly higher blastulation (38.93 versus 26.61%, p = .019) rate than TL group. We concluded that TL selection was beneficial to the patients with no good-quality embryos in the first cleavage-stage embryo transfers.

摘要

我们旨在评估延时选择是否对卵裂期胚胎移植有益。该研究纳入了从2018年1月至2019年8月的838名具有良好卵巢储备功能（获得8个以上的卵母细胞）的不育妇女, 并进行了相关研究。根据不同等级（I, II和III级）移植的胚胎, 将患者分为第3天常规形态学（conventional morphology, CM）选择组和第3天延时（time lapse, TL）选择组。对于I级和II级胚胎, 我们观察到CM和TL具有相似的着床、临床妊娠和持续妊娠率 (p > .05)。对于III级胚胎, 我们观察到CM组与TL组相比, 着床率（36.74%与41.03%, p=0.261）和临床妊娠率（56.82%与64.1%, p=0.182）略低。CM组持续妊娠率明显低于TL组（47.35%与59.83%, p=0.025）。CM组的囊胚形成率显著高于TL组（38.93%与26.61%, p=0.019）。我们的结论是, TL选择对首次分裂期胚胎移植中胚胎质量不佳的患者是有利的。

Keywords:

• Time lapse
• Day 3 embryo quality
• implantation
• clinical pregnancy
• ongoing pregnancy

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This project was supported by Shaanxi Technology Committee Industrial Public Relation Project (Project Number: 2018SF-260).