The biochemical pregnancy loss rate remains stable up irrespective of age and differs in pattern from clinical miscarriages

Abstract

Introduction

As women age, the increasing rate of aneuploidy lead to an augmentation in the incidence of clinical miscarriages. It was anticipated that biochemical pregnancy rates would also rise with maternal age. However, no study has previously evaluated the effect of maternal age on biochemical pregnancy rates.

Material and methods

A retrospective cohort study of 2177 subjects who underwent single embryo transfer (SET) as part of a fresh or thawed IVF cycle were recruited from 2008 through 2012, resulting in 952 pregnancies. Data was stratified for age and compared using analysis of variance (continuous data) and chi-squared tests (categorical data).

Results

The likelihood of a clinical miscarriage increased with age (p < .001). Surprisingly, advancing age had no effect on the biochemical pregnancy loss rate (p = .72) (Age 21–30 y: 10.7%, Age 31–35 y:9.8%, Age 36–40y:11.5%, Age 41–42 y:13.6%).

Conclusions

Biochemical pregnancy loss rate did not increase as a function of age in women 21 to 42 years of age.

摘要

引言：随着女性年龄的增长, 非整倍体发生率的增加导致临床流产发生率也随之增加。因此设想生化妊娠率也会随着产妇年龄的增长而增加。此前尚无产妇年龄对生化妊娠发生率影响的相关研究。

材料和方法：从2008年到2012年, 对2177名接受新鲜或解冻的IVF周期单胎移植（SET）的受试者进行了回顾性队列研究, 怀孕者952例。数据按年龄分层, 并使用方差分析(连续数据)和卡方检验(分类数据)进行比较。

结果：临床流产的可能性随着年龄的增加而增加（p <.001）。出人意料的是, 年龄增长对生化妊娠的丢失率没有影响（p = .72）（21-30岁：10.7％, 31-35岁：9.8％, 36-40y：11.5％, 41-42岁y：13.6％）。

结论：在21-42岁的女性中, 生化妊娠丢失率并不随年龄的增长而增加。

Keywords:

• Age
• in vitro fertilization
• biochemical pregnancy loss
• single embryo transfer

Disclosure statement

The authors disclose no conflict of interest.