Serum X-box-binding protein 1 levels in PCOS patients

Abstract

Objective

X-box binding protein-1 (XBP1) is a possible indicator of metabolic syndrome and diabetes. This study aimed to evaluate the relationship between serum XBP1 levels and polycystic ovary syndrome (PCOS).

Method

A prospective observational study was conducted with 88 patients. The first group was defined as the control group with ovulatory and normal-BMI patients (n = 28). The second group comprised of nonobese PCOS patients (n = 30). The third group included overweight/obese patients with PCOS (n = 30). Fasting plasma glucose, serum lipids, follicle stimulating hormone, luteinizing hormone, total testosterone, dehydroepiandrosterone and XBP1 levels l were evaluated in all groups.

Results

There was a significant difference in XBP1 levels between the study groups, and higher levels were observed both in the nonobese and obese PCOS groups than in the healthy controls (p < .001). The median level of XBP1 was 73.7 pg/ml in the control group, 114.11 pg/ml in the nonobese PCOS group, and 151.61 pg/ml in the overweight/obese PCOS group. A cutoff level of XBP1 at 95.79 pg/ml level was determined with a significant AUC (area under the curve) level of 99% and high specificity and sensitivity rates to predict PCOS. Also, a significant positive correlation was observed between XBP1 levels and BMI, waist circumference, fasting plasma glucose and triglyceride levels (p < .05).

Conclusions

XBP1 levels were significantly higher in PCOS patients, particularly in overweight/obese PCOS patients, than in the controls. Also, the parameters associated with metabolic syndrome were related to XBP1 levels.

多囊卵巢综合征患者血清X-盒结合蛋白1水平 摘要

目的：X-盒结合蛋白1（XBP1）是代谢综合征和糖尿病潜在的标志物。本研究旨在评估血清 XBP1 水平与多囊卵巢综合征(PCOS)之间的关系。

方法：对 88 名患者进行了一项前瞻性观察研究。第一组为对照组, 由排卵正常和BMI正常患者（n=28）组成。第二组由非肥胖 PCOS患者 (n=30) 组成。第三组由超重/肥胖PCOS患者 (n=30)组成。在所有组中评估空腹血糖、血脂、卵泡刺激素、促黄体生成素、总睾酮、脱氢表雄酮和XBP水平。

结果：各研究组之间的XBP1水平存在显著差异, 非肥胖和肥胖PCOS组的XBP1水平均高于健康对照组（p<.001）。XBP1中位水平在对照组中为73.7pg/ml, 在非肥胖PCOS组中为114.11pg/ml, 在超重/肥胖PCOS组中为151.61pg/ml。XBP1临界水平为95.79 pg/ml, AUC（曲线下面积）显著水平为99%, 预测PCOS的特异性和敏感性较高。此外, XBP1水平与 BMI、腰围、空腹血糖和甘油三酯水平之间观察到显著正相关（p <.05）。

结论：PCOS患者, 尤其是超重/肥胖PCOS患者, XBP1水平显著高于对照组。此外, 与代谢综合征有关的参数与XBP1水平有关。

Keywords:

• Polycystic ovary syndrome
• X-box protein 1
• ER stress
• insulin resistance

Disclosure Statement

This study was conducted in accordance with ethical standards and the Helsinki Declaration of 1975. The authors report no conflict of interest and declare that this study has not received financial support.