Abstract
Background
There are contradictory data concerning kisspeptin in gravids with preeclampsia and gestational hypertension (GH).
Objective
To conduct a meta-analysis of studies comparing maternal kisspeptin levels in gravids with and without preeclampsia or GH.
Material and methods
We searched PubMed, LILACS, and CNKI list of articles up to 20 August 2021, without language limitations, comparing circulating maternal kisspeptin levels, and maternal and neonatal outcomes in gravids with and without preeclampsia or GH. Meta-analyzed results are reported as standardized mean differences (SMD), and their 95% confidence interval (CI).
Results
Seven studies with a low-to-moderate risk of bias were eligible for meta-analysis. Gravids with preeclampsia or GH displayed significantly lower circulating kisspeptin levels (SMD, −0.68, 95% CI, −1.04 to −0.32), lower gestational ages at delivery (SMD, −2.22, 95% CI, −3.25 to −1.18), and birth weight (SMD, −2.16, 95% CI, −3.15 to −1.17), and significantly higher body mass indices (MD, 0.56, 95% CI, 0.24–0.88), systolic (SMD, 2.87, 95% CI, 2.22–3.53), and diastolic blood pressures (SMD, 2.57, 95% CI, 2.19–2.95).
Conclusion
Gravids with preeclampsia or GH had lower kisspeptin levels as compared to normotensive controls.
子痫前期和妊娠期高血压与母体循环低吻肽素水平相关:一项系统回顾和荟萃分析 摘要
背景:子痫前期和妊娠期高血压孕妇的吻肽素水平存在相互矛盾的数据。
目的: 对有无子痫前期或妊娠期高血压孕妇的吻肽素水平进行Meta分析。
材料和方法:我们检索PubMed、LILACS和中国知网上的截至2021年8月20日的无语言限制的文章列表, 比较有无子痫前期和妊娠期高血压的孕妇循环吻肽素水平和母婴结局。Meta分析结果报告为标准化均数差异( SMD )及其95 %可信区间( CI )
结果: 有七项低到中度偏倚风险的研究符合荟萃分析的要求。子痫前期或妊娠期高血压孕妇血清吻肽素水平显著降低(SMD, −0.68, 95% CI, −1.04 to −0.32), 分娩时胎龄显著降低(SMD, −2.22, 95% CI, −3.25 to −1.18), 出生体重显著降低(p < 0.05) (SMD, −2.16, 95% CI, −3.15 to −1.17),体重指数(MD, 0.56, 95% CI, 0.24–0.88)、收缩压(SMD, 2.87, 95% CI, 2.22–3.53)、舒张压(SMD, 2.57, 95% CI, 2.19–2.95)明显高于对照组。
结论:与血压正常的对照组相比, 子痫前期或妊娠期高血压孕妇的吻肽素水平较低。
Acknowledgments
Professor Farqad B. Hamdan, from the College of Medicine, Al-Nahrain University of Baghdad, Baghdad, Iraq, provided complementary information from reference [Citation40].
Author contributions
F.R.P.L., M.T.L.B., and R.S.C. conceived the study. F.R.P.L. and M.T.L.B. completed the PROSPERO protocol. All authors contributed to the study design. R.S.C., R.R.R., M.F.C., and F.R.P.L. carried out the data collection and guaranteed data integrity. M.T.L.B., F.R.P.L., and S.R.V. performed the statistical analysis. F.R.P.L. and R.S.C. wrote the first draft. All authors contributed to the revision and finalization of the manuscript. F.R.P.L. and R.S.C. guaranteed all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
Disclosure statement
The authors report no conflicts of interest and alone are responsible for the content and the writing of the article.