The therapeutic effect of granulocyte colony stimulating factor (G-CSF) on potential biochemical pregnancy in patients with unexplained repeated transplantation failure (RIF): a case series and literature review

Abstract

Background

Biochemical pregnancy is a type of embryo transfer failure, patients with unexplained repeated implantation failure (RIF) also have higher biochemical pregnancy rate. Our study intends to evaluate the effect of granulocyte colony-stimulating factor (G-CSF) in patients with unexplained RIF with low hCG levels in early pregnancy.

Methods

Unexplained RIF patients with low hCG levels after embryo transfer were allocated. G-CSF were administrated from the ninth days after embryo transfer. Clinical pregnancy, miscarriage and live birth rates were evaluated.

Results

The clinical pregnancy and live birth rates were 52.5% and 30%.

Conclusion

G-CSF is an effective treatment for potential biochemical pregnancy in unexplained RIF patients.

摘要

背景：生化妊娠是胚胎移植失败的一种类型, 不明原因的反复着床失败（RIF）患者也有较高的生化妊娠率。本研究旨在评价粒细胞集落刺激因子(G-CSF)对妊娠早期hCG水平低下的不明原因RIF患者的治疗效果。

方法：纳入胚胎移植后hCG水平低的不明原因RIF患者。从胚胎移植后第9天开始应用G-CSF。评估临床妊娠率、流产率和活产率。

结果：临床妊娠率为52.5%, 活产率为30%。

结论：G-CSF是治疗不明原因RIF潜在生化妊娠的有效方法。

Keywords:

• Repeated implantation failure (RIF)
• granulocyte colony-stimulating factor (G-CSF)
• biochemical pregnancy
• clinical pregnancy rate
• live birth rate

Ethics approval

The Ethics Committee of Women’s Hospital, Zhejiang University School of Medicine, approved the study.

Consent form

Written informed consent was obtained from all participants.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Additional information

Funding

Grant support was provided by the National Natural Science Foundation of China (No. 81701442, 81802593), and the Science Foundation for Distinguished Young Scholars of Zhejiang Province (No.LR14H040001).