Nutraceuticals and polycystic ovary syndrome: a systematic review of the literature

Abstract

Background

This study proposes a review of nutraceuticals used in the treatment of typical symptoms of Polycystic Ovary Syndrome (PCOS).

The aim is to provide a classification of the most widely used nutraceutical supplements identifying the most effective nutraceuticals on glucose and insulin metabolism, the androgenic hormone profile, fertility, ovulatory capacity, inflammation, and oxidative stress.

Material and Methods

We included randomized controlled trials on PCOS patients undergoing administration of nutraceuticals, in particular vitamin D, vitamin E, probiotics, and inositols. These administrations are variable in terms of dosage, single supplementation, or combined with other compounds, dosage, and duration of the intervention.

Results

The supplementation of inositols, at the physiologic ratio of 40: 1 of myo- and D-chiro-inositols, resulted to be the most effective in improving the glucose homeostasis and fertility, with a restoration of ovulatory capacity and menstrual regularity. Other nutraceuticals are particularly effective in reducing hyperandrogenism, with promising results demonstrated by the combinations of vitamin D and probiotics, vitamin E and coenzyme Q10, and the enrichment of inositol therapy with group B vitamins. An improvement in the inflammatory status and antioxidant capacity is obtained with the co-supplementation of probiotics and selenium or with vitamin E combined with omega 3.

Conclusions

Inositol supplementation is effective in the treatment of insulin resistance and fertility. Probiotics reduced hyperandrogenism, inflammatory and oxidative conditions, and resulted more effective when combined with selenium. Although these results proved to be satisfactory, further studies are needed with larger samples and a more homogeneous analysis of the outcomes.

摘要

背景：

背景：本研究对用于治疗多囊卵巢综合征 (PCOS) 典型症状的保健品进行了综述。

目的是提供最广泛使用的营养补充剂的分类, 确定对葡萄糖和胰岛素代谢、雄激素谱、生育能力、排卵能力、炎症和氧化应激最有效的营养补充剂。

材料和方法：

我们纳入了对 PCOS 患者进行营养保健品给药的随机对照试验, 特别是维生素 D、维生素 E、益生菌和肌醇。这些给药在剂量、单一补充或与其他化合物组合、剂量和干预持续时间方面是可变的。.

结果

以 40:1的肌醇和 D-手性肌醇的生理比例补充肌醇, 在改善葡萄糖稳态和生育能力方面最有效, 并恢复了排卵能力和月经规律。其他营养保健品如：维生素 D 和益生菌、维生素 E 和辅酶 Q10 的组合以及肌醇治疗与 B族维生素的联合使用对降低雄激素方面特别有效。益生菌和硒的共同补充或维生素E与omega 3的联合补充可改善炎症状态和抗氧化能力。

结论

补充肌醇可有效治疗胰岛素抵抗和生育能力。益生菌可减少雄激素过多症, 炎症和氧化状态, 并与硒结合使用更有效。尽管这些结果被证明是令人满意的, 但仍需要通过更大的样本量和结果的一致性分析来进行深入的研究。

Keywords:

• Nutraceuticals
• PCOS
• inositol
• vitamin D
• probiotics
• vitamin E

关键词:

• 营养保健品
• 多囊卵巢综合征
• 肌醇
• 维生素D
• 益生菌
• 维生素E

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The author(s) reported there is no funding associated with the work featured in this article.