Abstract
Objective: This study is aimed to examine the associations between embryo outcomes and serum sex hormone-binding globulin (SHBG) changes during progestin-primed ovarian stimulation (PPOS) protocols in IVF/ICSI cycles.
Research methods: This study included 2790 eligible consecutive cycles of patients aged 21–53 years undergoing PPOS treatment. Multivariable linear regression analysis was performed to explore the association between SHBG changes and embryo outcomes.
Results of the study: Our results showed that the SHBG-increase rate on the HCG day and in the late follicular phase were positively and linearly correlated with available embryos in day3, with adjusted regression coefficients (β) for the SHBG-increase rate on the HCG day, in the late follicular phase were 0.6 (0.4, 0.9), 0.4 (0.2, 0.6), but in the middle follicular phase and in the early follicular phase, this correlation was not significant (p > 0.05).
Conclusion: Our results indicate that serum SHBG increment may serve as a biomarker of the developmental potential of the oocytes from patients undergoing the PPOS protocol.
摘要
目的
本研究旨在探讨在体外受精/卵母细胞胞浆内单精子注射周期中, 孕激素诱导卵巢刺激(PPOS)期间, 胚胎结局与血清性激素结合球蛋白(SHBG)变化的关系。
研究方法
本研究纳入了2790例21-53岁接受PPOS处理的符合条件的连续周期患者。采用多元线性回归分析SHBG变化与胚胎预后间的关系。
研究结果
我们的结果显示, HCG日和卵泡晚期SHBG增比与第3天可用胚胎数呈线性正相关, 校正后HCG日和卵泡晚期SHBG增比的回归系数(β)分别是0.6(0.4, 0.9)、0.4(0.2, 0.6), 但是在卵泡中期和卵泡早期相关性不显著(p>0.05)。
结论
我们的结果表明血清SHBG的增加可作为采用PPOS方案的患者卵母细胞发育潜能的生物标志物。
Disclosure statement
There is no conflict of interest.