The role of paraoxonase and myeloperoxidase as oxidative stress markers in pregnant women with hypothyroidism

Abstract

Objective: This study aims to measure paraoxonase 1 (PON 1) and myeloperoxidase (MPO) levels in patients diagnosed with hypothyroidism during pregnancy by spectrophotometric method and to compare the results with healthy controls. Methods: For the study, the blood samples of 45 hypothyroid pregnant patients and 45 healthy control pregnant individuals who were compatible with the patient group in terms of age were taken. PON 1 and MPO levels in both groups were measured using spectrophotometric methods and statistical analysis was performed. Results: Serum PON 1 activity levels were significantly lower in hypothyroid pregnant patients than in the control group (p=.020). The patients group had significantly higher serum MPO concentrations than in control group (p=.020). MPO/PON-1 ratio was higher in pregnant patients with hypothyroidism than in the control group (p=.030). Conclusion: Decreased levels of PON1 with increased levels of MPO in hypothyroid pregnant patients suggest the critical role of oxidative stress in hypothyroidism during pregnancy.

摘要

目的

本研究采用分光光度法检测妊娠期甲减患者血清对氧磷酶1（PON 1）和髓过氧化物酶（MPO）水平, 并与正常对照组进行比较。

方法

本研究采集45名妊娠期甲减患者和45名健康对照孕妇的血液样本, 两组孕妇年龄上相匹配。采用分光光度法检测两组的PON-1和MPO水平, 并进行统计学分析。

结果

妊娠期甲减患者血清PON1活性水平显著低于对照组（p=0.020）。妊娠期甲减患者血清MPO浓度显著高于对照组（p=0.020）。妊娠期甲减患者MPO/PON-1比值显著高于对照组（p=0.030）。

结论

妊娠期甲减患者PON1水平降低, MPO水平升高, 提示氧化应激在妊娠期甲状腺功能减退症中起关键作用。

Keywords:

• hypothyroidism
• pregnancy
• paraoxonase
• myeloperoxidase

关键词:

• 甲状腺功能减退症
• 妊娠
• 对氧磷酶
• 髓过氧化物酶

Disclosure statement

No potential conflict of interest was reported by the authors.

Funding

The author(s) reported there is no funding associated with the work featured in this article.