Advancement of platelet-inspired nanomedicine

Abstract

Human platelets play important roles in several physiologic and pathologic processes. Any defects in platelet number and function can lead to a variety of bleeding complications; platelet transfusions are commonly used to improve platelet count and hemostatic function in these cases. However, transfusions are complicated by the short storage life of donated platelets and contamination risks. Synthetic platelet substitutes can render efficient hemostasis while allowing advantages of large-scale preparation, minimum contamination risk via effective sterilization, longer shelf-life, no need for blood type matching, and reduced risks of biologic or pathologic side effects. Recent efforts in synthetic platelet design have additionally focused on applications including hemostasis, drug delivery, and targeted delivery of cancer therapeutics. In the present review, we summarize the advancement of platelet-inspired nanomedicine for artificial blood component, tumor research, and treatment of thrombi.

Keywords:

• Artificial blood component
• mimic
• nanomedicine
• platelet
• thrombi
• tumor

Conflict of interest

The authors have no conflicts of interest to declare.

Additional information

Funding

This work was supported by the PLA Major Project (number: ANJ13J001), General Program of Nanjing General Hospital (number: YYMS2014012), and National Natural Science Foundation of China (number: 81600161).