Abstract
Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated that thrombocytopenia was associated with the prognosis of influenza cases, but the related evidence of platelet change within the course of the disease remains largely insufficient. A total of 130 laboratory-confirmed H7N9 cases and their corresponding medical records from August 2013 to March 2015 were collected from 23 hospitals of 13 cities in Guangdong, China. The results indicated that there was a significant difference between the outcome of H7N9 cases and their average platelet count (PC) including maximum, minimum, range, admission and discharge/death of the PC value. Furthermore, we built a classification and regression tree (CART) model to predict the fatality rate which varied with average PC. There was a 7% chance for a mortality from H7N9 if PC was over 207.0 × 10^9/L, while there was a 46.3% chance of a mortality from H7N9 when PC was between 123.9 × 10^9/L and 207.0 × 10^9/L, and 81.3% chance of a mortality from H7N9 when PC was less than 123.9 × 10^9/L. This study demonstrates that using platelet count to predict the fatality of H7N9 is significant, and lower platelet counts of H7N9 patients were associated with higher risk of mortality of H7N9 patients, which may need to be taken into consideration when planning clinical treatment.
Acknowledgements
We thank the Australia China Center for Public Health (ACCPH) for supporting the project. The authors would also like to thank Callan Davis from the Queensland University of Technology at Brisbane for his assistance in language polishing.
Authorship
Contribution: W.H. designed the study and helped to write the article; J.L. supported the study and helped to collect the data; Y.C. analyzed the data and helped to write the article; Y.Y. collected the data; J.C. helped to write the article.
Conflict of Interest
The authors declare that they have no conflicts of interest.
Supplementary material
The supplemental data for this article can be accessed here.