![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Mechanisms related to platelet release in the context of the bone marrow niche are not completely known. In this review we discuss what has been discovered about four critical aspects of this process: 1) the bone marrow niche organization, 2) the role of the extracellular matrix components, 3) the mechanisms by which megakaryocytes release platelets and 4) the novel approaches to mimic the bone marrow environment and produce platelets ex vivo.
Acknowledgments
This paper was supported by H2020-FETOPEN-1-2016-2017-SilkFusion
Declaration of interests
The authors report no conflicts of interest
Additional information
Funding
This work was supported by the H2020 Future and Emerging Technologies [H2020-FETOPEN-1-2016-2017-SilkFusion - Project ID 767309].