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Abstract
The effect of a probiotic prepared with Bacillus cereus on the immunity induced by a swine colibacillosis bacterin was tested in mice. The animals were vaccinated with 1/20th of a pig dose, and the immune responses evaluated by ELISA and by the skin delayed type hypersensitivity test. Probiotic-fed animals showed higher seroconversions (P< 0.05) to E. coli F4 and F41, but not to F5 and F6 antigens. The probiotic did not influence the concentration of total immunoglobulins in unvaccinated animals or the skin test in vaccinees. Highly and poorly reactive animals were detected within each experimental group. The results suggest that probiotic CenBiot may be useful not only in controlling digestive diseases but also to enhance humoral immunity against systemic infections in farm animals.