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Food and Agricultural Immunology Volume 26, 2015 - Issue 5
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Original Articles

Effects of antibacterial peptide on humoral immunity in weaned piglets

W. YuanCollege of Veterinary Medicine, Sichuan Agricultural University, Ya'an625014, PR China;Sichuan Province Key Laboratory of Animal Disease & Human Health, Sichuan Agricultural University, Ya'an625014, PR China;Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Ya'an625014, PR ChinaView further author information
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H. T. JinCollege of Veterinary Medicine, Sichuan Agricultural University, Ya'an625014, PR China;Sichuan Province Key Laboratory of Animal Disease & Human Health, Sichuan Agricultural University, Ya'an625014, PR China;Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Ya'an625014, PR ChinaView further author information
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Z. H. RenCollege of Veterinary Medicine, Sichuan Agricultural University, Ya'an625014, PR China;Sichuan Province Key Laboratory of Animal Disease & Human Health, Sichuan Agricultural University, Ya'an625014, PR China;Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Ya'an625014, PR ChinaView further author information
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J. L. DengCollege of Veterinary Medicine, Sichuan Agricultural University, Ya'an625014, PR China;Sichuan Province Key Laboratory of Animal Disease & Human Health, Sichuan Agricultural University, Ya'an625014, PR China;Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Ya'an625014, PR ChinaCorrespondence[email protected]
View further author information
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Z. C. ZuoCollege of Veterinary Medicine, Sichuan Agricultural University, Ya'an625014, PR China;Sichuan Province Key Laboratory of Animal Disease & Human Health, Sichuan Agricultural University, Ya'an625014, PR China;Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Ya'an625014, PR ChinaView further author information
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Y. WangCollege of Veterinary Medicine, Sichuan Agricultural University, Ya'an625014, PR China;Sichuan Province Key Laboratory of Animal Disease & Human Health, Sichuan Agricultural University, Ya'an625014, PR China;Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Ya'an625014, PR ChinaView further author information
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H. D. DengCollege of Veterinary Medicine, Sichuan Agricultural University, Ya'an625014, PR China;Sichuan Province Key Laboratory of Animal Disease & Human Health, Sichuan Agricultural University, Ya'an625014, PR China;Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Ya'an625014, PR ChinaView further author information
&
Y. T. DengCollege of Veterinary Medicine, Sichuan Agricultural University, Ya'an625014, PR China;Sichuan Province Key Laboratory of Animal Disease & Human Health, Sichuan Agricultural University, Ya'an625014, PR China;Key Laboratory of Environmental Hazard and Human Health of Sichuan Province, Sichuan Agricultural University, Ya'an625014, PR ChinaView further author information
 show all
Pages 682-689 | Received 22 Oct 2014, Accepted 10 Jan 2015, Published online: 11 Feb 2015
 
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Abstract

The aim of this study was to investigate the effects of dietary antimicrobial peptide (AMP) supplementation on the serum IgG, IgM, IgA, classical swine fever antibody (CSF-Ab), and total complement (CH50) levels in weaned piglets. Ninety weaned piglets were randomly allotted to five groups for 28-day study. Blood samples were collected at 32, 39, 46, and 53 days of age. The results showed that AMP as dietary additive increased the levels of IgG, IgM, IgA, CSF-Ab, CH50 among the whole experimental period, and the effects of AMP supplementation were dose-dependent. The study showed that supplementing weaned piglets diets with AMP enhanced the humoral immune responses of weaned piglets by improving the levels of classical swine fever virus antibody, CH50, and immunoglobulins. We suggest the dosage of AMP was 500 mg/kg.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The present work was supported by the Changjiang Scholars & Innovative Research Team of Ministry of Education of China Funds [grant number IRTO848].

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