Low body mass index and efavirenz use are independently associated with self-reported fatigue in HIV-infected patients

Supplemental data for this article can be accessed at https://doi.org/10.1080/09540121.2018.1524110.

ABSTRACT

This retrospective cohort study was conducted from January 2009 to July 2016 to explore the occurrence and risk factors of self-reported fatigue within the first 6 months after receiving antiretroviral treatment (ART) among patients living with HIV in Taizhou City of Zhejiang province, Eastern China. In total, 1163 HIV-infected patients with a median follow-up duration of 27.8 months were included in the analysis. Among them, 261 (22.4%) reported fatigue within the first 6 months after ART. In the multivariable logistic regression analysis, self-reported fatigue within the first 6 months after ART was negatively associated with junior middle-school education or above, baseline CD4 cell count of 200–349 and >350 cells/μL (vs < 200 cells/μL), overweight at baseline (vs normal weight) but positively associated with ≥50 years old at initiation of ART (vs <30 years old), underweight at baseline, use of efavirenz (EFV) in the first-line regimen. Our data suggest that earlier initiation of ART and higher body mass index are preferred to restore the energy of HIV-infected patients with the EFV use in the era of ART in China.

KEYWORDS:

• Human immunodeficiency virus
• self-reported fatigue
• efavirenz
• body mass index

Disclosure statement

No potential conflict of interest was reported by the authors.

Notes

Supplemental data for this article can be accessed at https://doi.org/10.1080/09540121.2018.1524110.

Additional information

Funding

This work was supported by the Shanghai Municipal Health and Family Planning Commission [grant number GWTD2015S05] and the National Natural Science Foundation of China [grant number 81373062].