Diabetes mellitus control in a large cohort of people with HIV in care-Washington, D.C.

ABSTRACT

With more effective antiretroviral therapy (ART), people with HIV (PWH) are living longer and have more chronic diseases, including diabetes mellitus (DM). The prevalence of DM has been estimated in PWH previously, however there is less research regarding DM control. Our objectives were to determine the prevalence of DM and DM control and determine factors associated with DM control in a large urban cohort of PWH in care. We examined DC Cohort participants aged ≥18 years old to determine DM prevalence and to assess DM control (HbA1c measurement <7.0%). Demographic, clinical, and HIV-related factors associated with DM control were identified using multivariate logistic regression. The cohort of 5876 participants was predominantly male (71.3%), Non-Hispanic Black (78.1%) and had a median age of 52.0 years. DM prevalence was 17.4% (1023/5876). Among participants with recent HbA1c data available (39.9%) the proportion with DM control was 60.0% (245/408). In multivariate analysis, higher BMI (aOR: 0.47; 95% CI 0.28, 0.79) and use of non-insulin DM medication (aOR 0.43, 95% CI 0.25, 0.73) or insulin (aOR 0.010, 95% CI 0.04,0.24) compared to no medication use. Our findings suggest that individuals on medication for their DM likely need enhanced support to reach their treatment goals.

KEYWORDS:

• Diabetes
• Hemoglobin A1c
• metabolic
• comorbidities

Acknowledgements

Data on this poster were collected by the DC Cohort investigators and research staff located at: Cerner Corporation (Jeffery Binkley, Rob Taylor, Cheryl Akridge, Stacey Purinton, Qingjiang Hou, Jeff Naughton, David Parfitt); Children's National Medical Center Adolescent (Lawrence D'Angelo) and Pediatric (Natella Rahkmanina) clinics; The Senior Deputy Director of the DC Department of Health HIV/AIDS, Hepatitis, STD and TB Administration (Michael Kharfen); Family and Medical Counseling Service (Michael Serlin); Georgetown University (Princy Kumar); The George Washington University Medical Faculty Associates (David Parenti); The George Washington University Department of Epidemiology and Biostatistics (Alan Greenberg, Maria Jaurretche, Brittany Wilbourn, James Peterson, Morgan Byrne, Yan Ma); Howard University Adult Infectious Disease Clinic (Ronald Wilcox), and Pediatric Clinic (Sohail Rana); La Clinica Del Pueblo, (Ricardo Fernandez); MetroHealth (Annick Hebou); National Institutes of Health (Carl Dieffenbach, Henry Masur); Unity Health Care (Gebeyehu Teferi); Washington Health Institute (Jose Bordon); Washington Hospital Center (Maria Elena Ruiz); and Whitman-Walker Health (Stephen Abbott). We would also like to acknowledge the Research Assistants at all of the participating sites, the DC Cohort Community Advisory Board and the DC Cohort participants.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The DC Cohort is funded and supported by the National Institute of Allergy and Infectious Diseases: [grant number UM1 AI069503].