General and abdominal obesity and incident hypertension among people living with HIV on antiretroviral therapy

ABSTRACT

Hypertension is highly prevalent among people living with HIV (PLWH). We sought to characterize the hypertension incidence among PLWH on antiretroviral therapy, focusing on the effect of change in general and abdominal obesity on hypertension during follow-up. This was a prospective analysis of 229 treated PLWH aged over 40 years without hypertension at baseline. Overall a median follow-up of 2.9 years, 26.2% PLWH developed hypertension. In multivariable models, compared to those without obesity measures at both baseline and follow-up visit, PLWH with general obesity at both occasions (adjusted odds ratio [aOR] = 3.83, P = 0.006) or at baseline only (aOR = 5.45, P = 0.003), abdominal obesity (measured as waist circumference) at both occasions (aOR = 3.87, P = 0.001) or at follow-up only (aOR = 2.27; 9P = 0.060), abdominal obesity (measured as waist-to-hip ratio) at both occasions (aOR = 2.27, P = 0.077) were at increased risk of incident hypertension. Our data show that both general and abdominal obesity especially in the persistent status increase the hypertension risk in treated PLWH.

KEYWORDS:

• Hypertension
• HIV
• abdominal obesity
• general obesity

Acknowledgements

The authors thank all of the participants, coordinators, and administrators for their support and help during the research.

Data available on request due to privacy/ethical restrictions

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to [restrictions e.g., Their containing information that could compromise the privacy of research participants].

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Natural Science Foundation of China [grant number 81872671]; China National Science and Technology Major Projects on Infectious Diseases Natural Science Foundation of China Science and Technology Major Projects on Infectious Diseases [grant number 2018ZX10721102-004], and partially supported by Shanghai Municipal Health and Family Planning Commission [grant number GWTD2015S05] and Zhejiang Provincial Natural Science Foundation of China [grant number Y19H260001].