HIV infection among injecting drug users in north-east Malaysia, 1992

Abstract

Human immunodeficiency virus (HIV has spread widely among injecting drug users (IDUs) in countries to the north and west of the ‘Golden Triangle’ region of South-East Asia; it is likely to have spread southwards to Malaysia as wd In order to assess HIV seroprevalence among IDUs in north-east Malaysia and describe risk factors for HIV infection in this population, we performed a cross-sectional seroepidemiology study among 210 IDUs recruited at the detoxification ward of the General Hospital in the capital city of the north-eastern Malaysian state, Kelantan. Subjects were sequential entrants to the detoxification ward, interviewed about HIV risk behaviour, and tested for antibody to HIV and to syphilis. Nearly a third (62/210, 30%) of these IDUs were HIV seropositive. Three-quarter (159/210) had travelled to Thailand in the preceding 5 years, of whom 32% (51/159) were HIV seropositive; this was associated with injecting in Thailand, but not with sexual contact there. Of those who had not left Malaysia in the preceding 5 years, 26% (11/43) were HIV seropositive, a rate not significantly different from those who had travelled Travel within Malaysia was common (144/210, 69%) among IDUs interviewed, as was unsafe injecting and unsafe sexual behaviour (20% had shared injecting equipment and 21% had had unprotected intercourse) in other states. In every locale, rates of unsafe injecting behaviour we high (55% sharing in last month), even among those who knew they were HIV infected, and rates of condom usage were low (93% of 160 sexually active IDUs had never used a condom). Syphilis was not associated with HIV infection, but with contact with Thai prostitutes. On multivariate analysis, the major predictors of HIV seropositivity in these IDUs were multiple sharing partners, low income and few years of education. HIV has spread widely among IDUs in north-east Malaysia, most likely fuelled by spread from the north, and is associated with low socio-economic status. Endogenous spread is occurring among IDUs both within Kelantan and probably in other states, and risk behaviour is so frequent in this high prevalence population that rates of transmission arc likely to remain high. Without large scale prevention programmes, this epidemic among Malaysian IDUs could lead to a much larger and more general epidemic of HIV infection in Malaysia.