New advances in tau imaging in parkinsonism

Mikaeel ValliResearch Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada; ;Division of Brain, Imaging and Behaviour–Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Toronto, ON, Canada; ;Institute of Medical Science, University of Toronto, Toronto, ON, Canada;

Antonio P. StrafellaResearch Imaging Centre, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada; ;Division of Brain, Imaging and Behaviour–Systems Neuroscience, Krembil Research Institute, UHN, University of Toronto, Toronto, ON, Canada; ;Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ;Morton and Gloria Shulman Movement Disorder Unit & E.J. Safra Parkinson Disease Program, Neurology Division, Department of Medicine, Toronto Western Hospital, UHN, University of Toronto, Toronto, ON, CanadaCorrespondence[email protected]; [email protected]

Abstract

Currently, the differential diagnosis between atypical parkinsonisms and classical idiopathic Parkinson’s disease can be quite difficult because of the significant overlap of clinical presentation and symptoms. Neurodegenerative conditions, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and frontotemporal dementia (FTD), are primarily characterized by accumulation of tau protein in the brain. Recent imaging developments for tau pathology may provide a promising tool for the assessment of diagnosis, prognosis, and progression of these neurodegenerative disorders. This review will survey PET studies to describe the recent advances in the imaging of tau pathology in PSP, CBD, and FTD.

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Acknowledgements

This work was supported by Canadian Institutes of Health Research (MOP 136778). APS is supported by the Canada Research Chair program.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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New advances in tau imaging in parkinsonism

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