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Articles

Deferred time of delivery of biologic therapies in patients with stabilized psoriasis leads to a ‘perceived satisfaction’: a multicentric study

ORCID Icon, , , , , , & show all
Pages 415-419 | Received 19 Mar 2020, Accepted 17 Apr 2020, Published online: 29 Apr 2020
 

Abstract

Objective

Thanks to their specificity of action, biologic drugs often lead to complete clearance of psoriatic lesions. In order to maintain its effectiveness, biological therapies cannot be discontinued. The aim of the study was to investigate the effect of widening the administration window of four biologic drugs, thus improving the quality of life of psoriatic patients and satisfying their desire to feel free from the disease, without loss of effectiveness.

Methods

We performed a multicentric cohort study considering patients with moderate-severe plaque psoriasis and/or arthropathic psoriasis treated with infliximab, adalimumab, etanercept or ustekinumab. The study group included patients with stabilized psoriasis in which the administration regimen of the biologic drug was deferred. The control group included psoriatic patients treated according the product monograph.

Results

The percentage of relapses in case of deferred administration intervals was comparable to that of standard administration intervals. The delayed administration modality got a good psychological consensus from the patients themselves, that reported a greater ‘perceived satisfaction’. A consistent economic advantage was reported in case of prolonged administration intervals.

Conclusions

The administration of biologic drugs with prolonged intervals maintains the same effectiveness as standard administration and produces a ‘perceived satisfaction’ in psoriatic patients.

Disclosure statement

The authors report no conflicts of interest.

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