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Case Reports

Axonal sensorimotor polyneuropathy after starting guselkumab

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Pages 2371-2372 | Received 21 Feb 2021, Accepted 29 Mar 2021, Published online: 01 Aug 2021
 

Abstract

Guselkumab is an IL-23 inhibitor that binds to the p19 subunit of IL-23 that is highly efficacious and well tolerated for the treatment of moderate-to-severe plaque psoriasis. We report a 20-year-old male who developed sensorimotor axonal polyneuropathy starting treatment with guselkumab, confirmed by neurological examination and serial neurophysiologic studies. His symptoms improved within 5 months of stopping the treatment. The neurophysiologic studies also showed improvement but with continued neuropathy and re-innervation changes on electromyography after about 10 months of stopping treatment. The time line of symptoms and a positive de-challenge are strong but not definitive evidence of guselkumab as a cause.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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