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Journal of Dermatological Treatment Volume 33, 2022 - Issue 4
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Articles

Downregulation of interleukin 36γ and its cleaver cathepsin G following treatment with narrow-band ultraviolet B phototherapy in psoriasis vulgaris

Mona El-Kaliobya Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt;b Kasr AL-Ainy Psoriasis Unit (KAPU), Dermatology Department, Faculty of Medicine, Cairo University, Cairo, EgyptCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9208-2458
ORCID Icon,
Mohamed H. M. EL-Komya Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt;b Kasr AL-Ainy Psoriasis Unit (KAPU), Dermatology Department, Faculty of Medicine, Cairo University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-9653-2938
ORCID Icon,
Eman R. Saida Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt;b Kasr AL-Ainy Psoriasis Unit (KAPU), Dermatology Department, Faculty of Medicine, Cairo University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-3521-5592
ORCID Icon,
Marwa Ahmed Amera Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt;b Kasr AL-Ainy Psoriasis Unit (KAPU), Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
,
Dina G. Saadia Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt;b Kasr AL-Ainy Psoriasis Unit (KAPU), Dermatology Department, Faculty of Medicine, Cairo University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0001-8774-0914
ORCID Icon,
Faisal Nouredin Mohammedc Department of Dermatology and Venereology, National Research Centre, Giza, Egypt
,
Laila A. Rashedd Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, EgyptORCID Iconhttps://orcid.org/0000-0002-0362-1385
ORCID Icon,
Eman D. El Desoukye Department of Epidemiology and Biostatistics, National Cancer Institute, Cairo University, Cairo, Egypt
&
Aya M. AlOrbania Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt;b Kasr AL-Ainy Psoriasis Unit (KAPU), Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
 show all
Pages 2358-2363 | Received 15 May 2021, Accepted 08 Aug 2021, Published online: 23 Aug 2021
 
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Abstract

Background

Growing evidence suggests the important role of IL-36 in the pathogenesis of psoriasis. Cathepsin G is a neutrophil-derived protease that can activate IL-36γ.

Objective

To assess the expression of IL-36γ and cathepsin G in psoriasis and to quantify the impact of treatment with narrow-band ultraviolet B phototherapy (NB-UVB) on their levels.

Methods

This case-control study involved 26 patients with moderate-severe psoriasis and 25 healthy volunteers. Psoriasis patients eligible for phototherapy received 24 NB-UVB sessions. Punch skin biopsies were obtained from all participants at recruitment and after phototherapy from patients. Real-time PCR was utilized for quantitative assessment of IL-36γ and cathepsin G expression in tissue samples.

Results

The expression of IL-36γ and cathepsin G was significantly higher in psoriasis before NB-UVB therapy compared to controls (p < .001). Both proteins decreased significantly with clinical improvement following NB-UVB therapy compared to baseline (p < .001). However, their expression after treatment was still higher than controls (p < .001).

Conclusion

IL-36γ and cathepsin G expression is upregulated in psoriatic lesions, supporting their role as mediators of inflammation in psoriasis. Downregulation of IL-36γ and cathepsin G is a possible mechanism for psoriasis improvement after NB-UVB therapy. IL-36 and cathepsin G can be considered as therapeutic targets for psoriasis.

Author contributions

All authors contributed significantly to the conception and the study design. Material preparation, data collection, and analysis were performed by Dina G Saadi, Mona El-Kalioby, Eman R Said, Marwa Ahmed Amer, Faisal Nouredin Mohammed, Laila A Rashed, Eman D El Desouky, and Aya M AlOrbani. The manuscript draft was first written by Mona El-Kalioby, Mohamed HM EL-Komy, Eman R Said, FaisalNouredin Mohammed, Aya M AlOrbani. All authors commented on the manuscript revisions and approved the final version of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

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