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| List of abbreviations | ||
| β-D-IAZGP: | = | beta-D-iodinated azomycin galactopyranoside |
| BFR: | = | blood flow rate |
| BOLD MRI: | = | blood oxygen level-dependent magnetic resonance imaging |
| CA-4P: | = | combretastatin |
| CA-IX: | = | carbonic anhydrase isozyme IX |
| CIP: | = | Cancer Imaging Program |
| COX-2: | = | cyclooxygenase 2 |
| CT: | = | computed tomography |
| Cu-ATSM: | = | copper (II) diacetyl-bis(N4)-methylthiosemicarbazone |
| Cu-PTSM: | = | copper (II) pyruvaldehyde-bis(N4)-methylthiosemicarbazone |
| DCE-MRI: | = | dynamic contrast-enhanced magnetic resonance imaging |
| DOTA: | = | 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid |
| DTPA: | = | diethylenetriamine pentaacetic acid |
| ECM: | = | extracellular matrix |
| EF5: | = | 2-(2-nitro-1H-imidazole-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide |
| EGFR: | = | epidermal growth factor receptor |
| EPR: | = | electron paramagnetic resonance |
| EPRI: | = | EPR imaging |
| FDG: | = | fluorodeoxyglucose |
| FETA: | = | fluoroetanidazole |
| 18F-FMISO: | = | 18F-labeled FMISO |
| FIH-1: | = | factor inhibiting HIF-1 |
| FMISO: | = | fluoromisonidazole |
| FREDOM: | = | fluorocarbon relaxometry using echo planar imaging for dynamic oxygen mapping |
| 5-FU: | = | 5-fluorouracil |
| Gd-BSA: | = | Gd-labeled bovine serum albumin |
| Gd-DTPA: | = | gadolinium-diethylenetriamine pentaacetic acid, also called gadopentate dimeglumine |
| GFP: | = | green fluorescent protein |
| GTV: | = | gross tumor volume |
| HBO: | = | hyperbaric oxygen |
| HCR: | = | hypoxic cytotoxicity ratio |
| HFB: | = | hexafluorobenzene |
| HGF: | = | hepatocyte growth factor |
| HIF: | = | hypoxia-induced factor |
| HMWCA: | = | high-molecular-weight contrast agent |
| HNSCC: | = | head and neck squamous cell carcinoma |
| HRE: | = | hypoxia response element |
| HSF: | = | hypoxic-specific factor |
| HSP: | = | heat shock protein |
| IAZA: | = | iodoazomycin arabinoside |
| IAZGP: | = | iodinated azomycin galactopyranoside |
| IFP: | = | interstitial fluid pressure |
| IMRT: | = | intensity-modulated radiation therapy |
| LiPc: | = | lithium phthalocyanine |
| MAPK: | = | mitogen-activated protein kinase |
| MMP: | = | matrix metalloproteinase |
| MRI: | = | magnetic resonance imaging |
| MRO2: | = | oxygen consumption rate |
| NCI: | = | National Cancer Institute |
| NMR: | = | nuclear magnetic resonance |
| [O2]1/2Max: | = | oxygen dependency |
| OMRI: | = | Overhauser-enhanced magnetic resonance imaging |
| OPN: | = | osteopontin |
| PET: | = | positron emission tomography |
| PFC: | = | perfluorocarbon |
| pO2: | = | partial pressure of oxygen |
| PSA: | = | prostate-specific antigen |
| PSP: | = | permeability surface area product |
| SMWCA: | = | small-molecular-weight contrast agent |
| SPECT: | = | single photon emission computed tomography |
| SUV: | = | standard uptake value |
| TPZ: | = | tirapazamine |
| VCAM: | = | vascular cell adhesion molecule |
| VEGF: | = | vascular endothelial growth factor |
| VHL: | = | von Hippel-Lindau |
| VV: | = | vascular volume |
Participants
Jeffrey M. Arbeit, MD
Professor of Surgery and Urology
Division of Urologic Surgery
Washington University School of Medicine
660 South Euclid Avenue, Box 8242
St. Louis, MO 63110-1093, USA
Tel: +1 314 362 3222
E-mail: [email protected]
J. Martin Brown, DPhil
Professor of Radiation Oncology
Department of Radiation Oncology
Stanford University School of Medicine
CCSR South, Room 1255
269 Campus Drive
Stanford, CA 94305-5152, USA
Tel: +1 650 723 5881
E-mail: [email protected]
K. S. Clifford Chao, MD
Associate Professor of Radiation Oncology
Head and Neck Center
University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard, Box 0097
Houston, TX 77030, USA
Tel: +1 713 563 2338
E-mail: [email protected]
J. Donald Chapman, PhD
President
CRM Consulting Services
144 Williamson Place
Penticton, British Columbia V2A 8N1
Canada
Tel: +1 250 493 7722
E-mail: [email protected]
William C. Eckelman, PhD
President
Molecular Tracer, LLC
Bethesda, MD, USA
Tel: +1 619 543 5330
E-mail: [email protected]
Anthony W. Fyles, MD
Research Professor
Ontario Cancer Institute
Princess Margaret Hospital
5th Floor, Room 5-984
610 University Avenue
Toronto, Ontario M5G 2M9, Canada
Tel: +1 416 946 4501 x6522
E-mail: [email protected]
Amato J. Giaccia, PhD
Director and Professor of Radiation Oncology
Department of Radiation Oncology
Stanford University School of Medicine
CCSR South, Room 1255
269 Campus Drive
Stanford, CA 94305-5152
Tel: +1 650 723 7366
E-mail: [email protected]
Robert J. Gillies, PhD
Professor of Biochemistry, Radiology, and Physiology
Director, Cancer Imaging and Technology Program
Arizona Cancer Center
1515 North Campbell Avenue
P.O. Box 245024
Tucson AZ 85724-5024, USA
Tel: +1 520 626 5050
E-mail: [email protected]
Richard P. Hill, PhD
Research Professor
Department of Research
Ontario Cancer Institute
Princess Margaret Hospital
610 University Avenue
Toronto, Ontario M5G 2M9
Canada
Tel: +1 416 946 2979
E-mail: [email protected]
Cameron J. Koch, PhD
Professor of Radiation Oncology
Department of Radiation Oncology
University of Pennsylvania
195 John Morgan Building
37th Street and Hamilton Walk
Philadelphia, PA 19104-6072USA
Tel: +1 215 898 0073 or 72
E-mail: [email protected]
Murali Cherukuri Krishna, PhD
Chief, Biophysical Spectroscopy Section
Radiation Biology Branch
Center for Cancer Research
National Cancer Institute
Building 10, Room B3B69
Bethesda, MD 20892-1002USA
Tel: +1 301 496 7511
E-mail: [email protected]
Kenneth A. Krohn, PhD
Professor of Radiology
Department of Chemistry
University of Washington
Box 356004
Seattle, WA 98195-6004, USA
Tel: +1 206 548 6245
E-mail: [email protected]
Jason S. Lewis, PhD
Assistant Professor
Mallinckrodt Institute of Radiology
Washington University School of Medicine
4424F Clinical Sciences Research Building
Campus Box 8225
St. Louis, MO 63110, USA
Tel: +1 314 3624696
E-mail: [email protected]
Ralph P. Mason, PhD
Professor of Radiology
The University of Texas Southwestern Medical Center at Dallas
5323 Harry Hines Boulevard
Dallas, TX 75390-9058, USA
Tel: +1 214 648 8926
E-mail: [email protected]
Giovanni Melillo, MD
Senior Investigator
Tumor Hypoxia Laboratory
Screening Technologies Branch
Developmental Therapeutics Program, DCTD
NCI-Frederick
Building 432, Room 218
Frederick, MD 21702-1201, USA
Tel: +1 301 846 5050
E-mail: [email protected]
Anwar R. Padhani, MD, PhD, MBBS
Clinical Head of MRI
Paul Strickland Scanner Centre
Mount Vernon Hospital
Rickmansworth Road
Northwood, Middlesex HA6 2RN
United Kingdom
Tel: +44 (0)1923 844751
E-mail: [email protected]
Garth Powis, DPhil
Director of Basic Research
Professor of Pathology, Pharmacology, Molecular and Cell Biology
Department of Pharmacology
Arizona Cancer Center
1515 North Campbell Avenue
P.O. Box 245024
Tucson, AZ 85724, USA
Tel: +1 520 626 6408
E-mail: [email protected]
Joseph G. Rajendran, MD
Nuclear Medicine Specialist
Department of Radiology
University of Washington Medical Center
Box 356113
1959 NE Pacific Street
Seattle, WA 98195-6113, USA
Tel: +1 206 598 4240
E-mail: [email protected]
Richard Reba, MD
Department of Radiology
Georgetown University Medical Center
Ground Floor, CCC Building
3800 Reservoir Road, NW
Washington, DC 20007, USA
Tel: +1 202 444 3360
E-mail: [email protected]
Gregg L. Semenza, MD, PhD
Center Investigator
Johns Hopkins NHLBI Proteomics Center
Johns Hopkins University School of Medicine
733 North Broadway Street
Broadway Research Building, Room 671
Baltimore, MD 21205, USA
Tel: +1 410 614 0214
E-mail: [email protected]
Harold M. Swartz, MD, PhD
Professor of Radiology, Community and Family Medicine, and Physiology
EPR Center for the Study of Viable Systems
Dartmouth Medical School
702 Vail
Hanover, NH 03755, USA
Tel: +1 603 650 1955
E-mail: [email protected]
Peter Vaupel, Dr Med, MD, MA
Professor and Chairman
Institute of Physiology and Pathophysiology
University of Mainz
Duesbergweg 6
55099 Mainz
Germany
Tel: +49 6131 3925929
E-mail: [email protected]
David Yang, PhD
Director, Radiopharmaceutical Development
Associate Professor of Experimental Diagnostic Imaging
University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard, Box 0057
Houston, TX 77030, USA
Tel: +1 713 794 1053
E-mail: [email protected]
Organizers
Gary Kelloff, MD
Advisor to Associate Director
Cancer Imaging Program
Division of Cancer Treatment and Diagnosis
National Cancer Institute
Executive Plaza North, Room 6058
6130 Executive Boulevard
Rockville, MD 20852-7412, USA
Tel: +1 301 594 0233
E-mail: [email protected]
Daniel Sullivan, MD
Associate Director
Cancer Imaging Program
Division of Cancer Treatment and Diagnosis
National Cancer Institute
Executive Plaza North, Room 6054
6130 Executive Boulevard
Rockville, MD 20852-7412, USA
Tel: +1 301 496 9531
E-mail: [email protected]
James Tatum, MD
Advisor to Associate Director
Cancer Imaging Program
Division of Cancer Treatment and Diagnosis
National Cancer Institute
Executive Plaza North, Room 6000
6130 Executive Boulevard
Rockville, MD 20852-7440, USA
Tel: +1 301 496 9531
E-mail: [email protected]
Workshop agenda
Hypoxia: Importance in tumor biology, non-invasive measurement by imaging, and value of its measurement in the management of cancer therapy
Robert J. Gillies, Chairman
Gary J. Kelloff and James L. Tatum, NCI Organizers
Day 1: Monday 5 April 2004
Survey of the presence and clinical significance of hypoxia in human cancer: Data from cervix, head & neck, pancreas, brain, breast, sarcomas, other
Anthony W. Fyles
Impact of hypoxia on therapy outcome: Overview and measurement of hypoxia
Peter W. Vaupel
Survey of the biology and molecular biology associated with hypoxia: Influence of hypoxia on tumor progression
Amato J. Giaccia
Survey of HIF-1α, 2α: Control, mode of action, downstream effects
Gregg L. Semenza
Modulation of microvascular biology by HIF-1alpha
Jeffrey M. Arbeit
Eppendorf (Gold standard??)
Richard P. Hill
What is the actual heterogeneity to be expected in tumors and how can we resolve it?
Harold M. Swartz
Non-invasive measurement of hypoxia by imaging #1 – imidazoles
J. Donald Chapman
Non-invasive measurement of hypoxia by imaging #2 – FMISO
Kenneth A. Krohn
Non-invasive measurement of hypoxia by imaging #3 – Cu-ATSM
Jason S. Lewis
Non-Invasive Measurement of Hypoxia by Imaging #4—EF-5
Cameron J. Koch
Non-invasive measurement of hypoxia by imaging #5 – F-19 MRI
Ralph P. Mason
Day 2: Tuesday 6 April 2004
Non-invasive measurement of hypoxia by imaging #7 – MRI-BOLD
Robert J. Gillies
Non-invasive measurement of hypoxia by imaging #6 – MRI-BOLD
Anwar R. Padhani
Non-invasive measurement of hypoxia by imaging #8 – EPRI
Murali C. Krishna
Non-invasive measurement of hypoxia by imaging #9 – EPR spectroscopy
Harold M. Swartz
What happens to hypoxia during a course of treatment
Joseph G. Rajendran
HIF-1α inhibitors
Garth Powis
Inhibitors of HIF-1 transcriptional pathways
Giovanni Melillo
Tirapazamine
J. Martin Brown
Practical issues related to hypoxia imaging guided radiotherapy
K. S. Clifford Chao
Round Table: Clinical protocols for evaluating and validating non-invasive measurements of hypoxia
Cervix, Head & Neck, Breast, Brain, Lung, Prostate, Colon, Other
(Co-Chairs – William C. Eckelman and Robert J. Gillies)
Round Table: Clinical protocols in clinical treatment settings where measurement of hypoxia would be of most value in treatment management
Cervix, Head & Neck, Breast, Brain, Lung, Prostate, Colon, Other
(Co-Chairs – J. Martin Brown and Anthony J. Fyles)
