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Abstract
Aim: The Pasche research group has reported that tumor-specific electromagnetic field frequencies have physiological and potential anti-tumor effects in cells, animals, and humans. Our aim was to investigate whether these fields have similar effects on physiological parameters in murine tumor models.
Methods: Human HuH7 or HEPG2 cells were implanted in the right flank of 8-week-old female RAG gamma 2 C immunodeficient mice. An oximeter was used to record systolic blood pressure (pulse) in free-roaming conscious mice. Mice pulses were recorded and analyzed using a in-house software that also controlled the low-frequency generator for modulating the 27.12 MHz carrier wave at selected frequencies.
Results: We performed exposures using both systematic scans at low frequencies and at the pre-determined frequencies reported by the Pasche group as altering both pulse and tumor growth in humans. Those exposures produced no detectable change in physiological parameters of tumor-bearing mice.
Conclusion: No tumor-related frequencies were found, neither using systematic scans of frequencies nor published specific frequencies. There might obviously be differences between animal and human models, but our approach did not confirm the physiological data of the human Pasche group data.
Acknowledgements
The authors thank Antonio Šarolić, FESB, University of Split, Croatia, and Michal Teplan, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, for providing insightful comments and reviewing the manuscript. Neither of them received any compensation for their work. Oral presentation: 2014 Annual Meeting of the Bioelectromagnetics Society, Cape Town, South Africa; COST EMF-MED Workshops and Meetings: 14–16 February 2017, Warsaw, Poland.
Disclosure statement
No potential conflict of interest was reported by the authors.
Additional information
Notes on contributors
Bernard Veyret
Bernard Veyret, PhD, joined the CNRS in 1979. Following a postdoctoral fellowship in Cambridge, England, he has developed his research activity in bioelectromagnetics in Bordeaux, using in-vitro and in-vivo models. He was a member of the ICNIRP for 12 years.
Delia Arnaud-Cormos
Delia Arnaud-Cormos, PhD, is an Associate Professor in the Xlim Research Institute, University of Limoges, France. Since 2018, she is a junior member of the Institut Universitaire de France (IUF). Her research interests concern nanosecond pulses/microwave exposure systems set-up and dosimetric characterization for bioelectromagnetic studies.
Emmanuelle Poque
Emmanuelle Poque is a Biologist Engineer at the Polytechnic Institute of Bordeaux (Bordeaux INP), working on bioelectromagnetics at the cellular and molecular levels.
Florence Poulletier de Gannes
Florence Poulletier de Gannes, PhD, is a CNRS Research Engineer at the IMS laboratory. Her research deals mainly with the adverse and beneficial biological effects of non-invasive electromagnetic fields funded by several national and foreign programmes. She also works on EMF health risk assessment.
Annabelle Hurtier
Annabelle Hurtier is a Bordeaux INP Biologist Technician at the IMS laboratory. She is in charge of animal facility and is a specialist in animal welfare.
Rodolphe Decourt
Rodolphe Decourt, PhD, is a CNRS Electronic and Computing Research Engineer working at Bordeaux University. He is specialized in low level electronics, data acquisition and scientific computing.
Sokha Khiev
Sokha Khiev is a Research Engineer working at Bordeaux University. He is in charge of the Cleanroom ELORPrintTec in Bordeaux which is specialized in printed organic electronics.
Gilles N’Kaoua
Gilles N'Kaoua is an Electronic Research Engineer working at Bordeaux University. He is working on “Neuromorphic Engineering”. He also is responsible of the CNRS Electronics engineers Network since 2016.
Isabelle Lagroye
Isabelle Lagroye, PhD, is a Director of studies at the Ecole Pratique des Hautes Etudes (EPHE) working at Bordeaux University, France. Her research deals mainly with the biological and toxicological effects of non-invasive electromagnetic fields. She is currently member of the Bruxelles-Capitale expert committee on non-ionising radiations.
Philippe Lévêque
Philippe Lévêque, PhD, is a CNRS Senior Scientist and the group leader of the BioEM group working on nanopulse applications in the XLIM Research Institute, University of Limoges. He is involved in the development of dosimetry and exposure setups for health-risk assessment in cooperation with biological and medical research groups.
Yann Percherancier
Yann Percherancier, PhD, is a CNRS Senior Scientist and is working at Bordeaux University (France). His main research focus on deciphering the effects of low-level electromagnetic fields on living matter at the cellular and molecular level.
