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Summary
The concept of cellular viability is extremely complex and has been the subject of much speculation. A new theory is proposed to interpret cellular injury and killing process. Factors that interfere with or extensively modify cellular organization and reactions can be considered, in a biological sense, to injure or kill the cell. Such interference may result from the interaction of cellular molecules with a multitude of agents. In the terms of functional sub-units of the cell the following changes may take place: (1) inactivation or alteration of enzymes, (2) modification of templates for synthetic process, and (3) alteration and decomposition of metabolites, intermediates and co-factors.
An analysis is made of how cellular processes may be affected by external agents and how functional disorganizations may occur. It is proposed that there is a relation between the phenomenon of functional disorganization and cellular injury and death.