On the Mechanism of the Radioprotective Action of Cyanide

C. van der Meer Medical Biological Laboratory of the National Defence Research Organization T.N.O., Lange Kleiweg 139, Rijswijk (Z.H.), The Netherlands

O. Brocades Zaalberg Radiobiological Institute of the Organization for Health Research T.N.O., Lange Kleiweg 151, Rijswijk (Z.H.), The Netherlands

O. Vos Medical Biological Laboratory of the National Defence Research Organization T.N.O., Lange Kleiweg 139, Rijswijk (Z.H.), The Netherlands

A.J. Vergroesen Radiobiological Institute of the Organization for Health Research T.N.O., Lange Kleiweg 151, Rijswijk (Z.H.), The Netherlands

D.W. van Bekkum Medical Biological Laboratory of the National Defence Research Organization T.N.O., Lange Kleiweg 139, Rijswijk (Z.H.), The Netherlands

Summary

The mechanism of the radioprotective action of cyanide has been investigated with rat-thymocyte suspensions, cultured human-kidney cells and with mice.

Cyanide does not protect cells in vitro. In the thymocyte system, cyanide has instead a slight radiosensitizing action. The presence of cyanide after the irradiation causes an inhibition of the development of eosin permeability.

In mice, cyanide produces a hypoxia of the spleen and bone-marrow. This hypoxia explains the protection against a lethal dose of x-rays.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

On the Mechanism of the Radioprotective Action of Cyanide

Information for

Open access

Opportunities

Help and information

On the Mechanism of the Radioprotective Action of Cyanide

Summary

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature