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Summary
(1) Mean SGOT and SGPT values in normal mice were 99·3 ± 4·7 and 43·1 ± 1·1 units/ml respectively.
(2) Both showed significant increases during 24 hours following whole-body doses of 500 or 1000 r x-rays.
(3) Six hours after 1000 r, the mean SGOT value reached 139·9 ± 2·5 units/ml in unprotected mice, but only 122·0 ± 2·5 units/ml in AET-protected.
(4) The SGOT increase at 6 hours did not appear to vary linearly with dose, and may show a saturation type reponse. Therefore AET may protect SGOT-liberating tissues otherwise than by dose-reduction.
(5) The degree of uniformity both of the radiation response of mouse SGOT, and of its reduction by AET, suggests that the system may provide a quick way of detecting or comparing radioprotectors.