6
Views
15
CrossRef citations to date
0
Altmetric
Original Article

The Response to Continuous Irradiation of the Mouse Lymphoma L 5178Y Grown in Vitro

Pages 581-592 | Received 26 Apr 1965, Published online: 03 Jul 2009
 

Summary

A radiosensitive strain of the mouse lymphoma L 5178Y grown in vitro was exposed to continuous gamma-radiation at dose-rates of 3·0 and 6·3 r/hr. At 6·3 r/hr the number of living cells decreased, but at 3·0 r/hr the culture continued to grow exponentially, although more slowly than normal. Irradiation was continued for a period of over 10 months, during which time the culture showed no signs of deterioration in so far as ability to proliferate was concerned. It was concluded that, for this rapidly-dividing culture, there was no accumulation of radiation damage.

The radiosensitivity of the culture was tested at 1½ and 3 months from the start of irradiation and was found to be unchanged, but at 6 months the culture had become resistant. Growth-rate measurements on the resistant culture suggested that under conditions of continuous irradiation the cell-cycle time was prolonged.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.