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Summary
The activity of two dehydrogenase systems of the pentose cycle (glucose-6-phosphate-dependent and 6-phosphogluconate-dependent) was studied in homogenates of four regions of the adult male rat gastrointestinal tract following 1540 rads whole-body x-irradiation (WBR), or 1400 rads mixed gamma-neutron irradiation. Microchemical assays using a tetrazolium salt (INT) were done at intervals after irradiation (10–20 min, 1, 2, 3 days). By day 1 post-irradiation there was a significant fall in activity in both pentose cycle systems in the stomach. For the most part, the fall in activity did not occur in the intestinal regions until the second day. This depression became most prominent by 3 days for the regions studied.
It appears from this study that the dehydrogenase systems which are extramitochondrial showed a lesser depression in activity than did those which are intramitochondrial and which have been reported in a previous paper.