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Summary
Monoamine oxidase inhibitors (iproniazid and trans-phenylcyclopropylamine, t-PCPA), injected into mice two hours before 5-hydroxytryptamine (5-HT), do not alter the maximum radioprotective efficiency of the amine. However, the increased radioresistance of mice is much prolonged under these conditions. This effect was studied in dependance on time of the 5-HT application and on the dose of 5-HT.
Iproniazid and t-PCPA provoke a strong inhibition of the monoamine oxidase activity in vivo under the experimental conditions and 5-HT is taken up at a slower rate by the tissue. As a consequence, the level of 5-HT is increased in the tissues for a longer period.
From these data it can be deduced that metabolites formed from 5-HT via the degradation by monoamine oxidase do not induce or influence the radioprotective effect, and hypothermia caused by 5-HT is not responsible for the increased radioresistance of mice.