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Original Article

Late Somatic Effects in Syngeneic Radiation Chimaeras

II. Mortality and Rate of Specific Diseases

, , , &
Pages 1-15 | Received 07 Nov 1973, Accepted 20 Jan 1974, Published online: 03 Jul 2009
 

Summary

Short- and long-term pathological and epidemiological observations were conducted on a group of control hybrid mice and several groups of animals irradiated with 900 rads and injected with various doses of normal isogeneic bone-marrow stem-cells.

Bone-marrow transplantation was effective in enhancing the short-term survival of the treated animals. By comparison with the controls, the long-term survivors showed a shortened life-span, an increased incidence of degenerative and malignant neoplastic diseases and a reduced incidence of reticulum cell sarcoma.

The quantitative analysis of the data in terms of age-specific death-rate from all causes and/or with specific diseases provides a description of the basic features of a model of late radiation action, which allows the control of cellular variables and may be of potential interest in studies on radiation carcinogenesis and leukaemogenesis.

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