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International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Volume 27, 1975 - Issue 5
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Letter to Editor

Effects of X-rays on Ag-DNA Complexes

Harold Goff Department of Chemistry and Laboratory of Radiation Biology, University of Texas, Austin, Texas, 78712, U.S.A.
&
E.L. Powers Zoology Department, University of Texas, Austin, Texas, 78712, U.S.A.
Pages 503-507 | Received 26 Mar 1975, Accepted 10 Apr 1975, Published online: 03 Jul 2009
 
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Summary

Effects of 300 kVp X-radiation on silver(I)-complexed calf thymus DNA in neutral aqueous solution were determined by spectrophotometric and sedimentation methods. Complexed silver ion in the ratio of one Ag+: two DNA bases does not increase the radiosensitivity of DNA. Experiments with added N2O and alcohols implicate the hydroxyl radical as the most important damaging species in both native DNA and Ag+-bound DNA.

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