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Original Article

Double Strand-breaks and DNA-to-protein Cross-links Induced by Fast Neutrons in Bacteriophage DNA

Pages 1-13 | Received 26 Apr 1978, Accepted 23 Aug 1978, Published online: 03 Jul 2009
 

Summary

Coliphage T7 was suspended in tryptone broth and exposed to a mixture of fast neutrons and gamma radiation. Plaque survival, double strand-breaks and DNA-to-protein cross-linkage were examined and the results compared with those found in phage exposed to gamma radiation alone. Neutral sucrose density sedimentation patterns indicate that neutron-induced double strand-breaks sometimes occur in clusters of more than 100 in the same phage and that the effeciency with which double strand-breaks form is about 50 times that of gamma-induced double strand-breaks. Neutron-induced protein-to-DNA cross-links probably also occur in clusters with enhanced efficiency relative to low LET radiation.

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