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Original Article

The Triplet-state Charge-transfer Reaction between P-nitroacetophenone and Guanosine Monophosphate a Possible Mechanism for Electron-affinic Radiosensitization

Pages 265-271 | Received 07 Apr 1978, Accepted 28 Jun 1978, Published online: 03 Jul 2009
 

Summary

Using flash photolysis it has been observed that the triplet state of p-nitroacetophenone reacts rapidly with guanosine monophosphate to give the p-nitroacetophenone radical anion, and presumably the guanine radical cation is also formed in this reaction. From this observation, it is predicted by theory that a similar reaction will occur between p-nitroacetophenone and the triplet state of guanosine monophosphate. Because guanine is excited to its triplet state when DNA is irradiated with X-rays, it is suggested that the charge transfer reaction between p-nitroacetophenone and the triplet state of guanine contributes to the radiosensitizing action of p-nitroacetophenone.

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