Characterization of Feline Whole-blood Cultures and Determination of the Frequency of Radiation-induced Dicentrics in Human and Feline Lymphocytes

G. Stephan Institut für Strahlenhygiene, Bundesgesundheitsamt, D-8042, Neuherberg, F.R. Germany

I.-D. Adler Abteilung für Genetik, Gesellschaft für Strahlen- und Umweltforschung, D-8042, Neuherberg, F.R. Germany

D. Schwartz-Porsche Klinik und Poliklinik für kleine Haustiere, Freie Universität Berlin, D-1000, Berlin, F.R. Germany

K.-U. Hollihn Institut für Allgemeine Biologie und Genetik, Freie Universität Berlin, D-1000, Berlin, F.R. Germany

G. Obe Institut für Strahlenhygiene, Bundesgesundheitsamt, D-8042, Neuherberg, F.R. Germany

Summary

The Ham's F-10 and PHA culture system was applied to whole feline blood, and cell-cycle characteristics such as DNA synthesis and mitotic indices were studied. The results are comparable to those obtained from human whole-blood cultures. The yields of dicentrics were also determined in lymphocytes from X-irradiated human and feline blood. The ratio between the experimental yields of dicentrics in human as compared to feline lymphocytes was 1:0·27.

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Characterization of Feline Whole-blood Cultures and Determination of the Frequency of Radiation-induced Dicentrics in Human and Feline Lymphocytes

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Characterization of Feline Whole-blood Cultures and Determination of the Frequency of Radiation-induced Dicentrics in Human and Feline Lymphocytes

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