Whole Body Hyperthermia with a Microwave Regional Boost: Unexpected Toxicity in the Pig

H.I. Robins Department of Human Oncology, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, U.S.A.

L.M. Shecterle Department of Physiology, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, U.S.A.

J.P. Aubuchon Department of Pathology, Laboratory Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, U.S.A.

B.R. Paliwal Department of Medical Physics, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, U.S.A.

T.E. Davis Department of Human Oncology, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, U.S.A.

W.H. Dennis Department of Physiology, University of Wisconsin, 600 Highland Avenue, Madison, WI, 53792, U.S.A.

Summary

An animal model was used to investigate the potential for delivering a regional temperature boost using microwave energy after whole body hyperthermia had been induced in a pig using low density, radiant heat. Thermal profiles and an unexpected toxicity in the region of the microwave energy deposition, which included the heart and liver, are reported.

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Whole Body Hyperthermia with a Microwave Regional Boost: Unexpected Toxicity in the Pig

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