Differential Recovery from Potentially Lethal Damage in Normal Human Lung Fibroblasts after Irradiation with ⁶⁰Co γ-rays and Accelerated N-ion Beam

Tadao Ohno National Institute of Radiological Sciences, 4-9-1, Anagawa, Chibashi, 260, Japan

Tetsuji Nishimura The Institute of Physical and Chemical Research, 2-1, Hirosawa, Wakoshi, Saitama, 351, Japan

Kazushiro Nakano Institute of Public Health, 4-6-1, Shirokanedai, Minato-ku, Tokyo, 108, Japan

Ichiro Kaneko National Institute of Radiological Sciences, 4-9-1, Anagawa, Chibashi, 260, Japan

Summary

PLD recovery after irradiation with accelerated N-ion was examined and compared with that after irradiation with ⁶⁰Co γ-rays in normal human lung fibroblasts (IMR-90). No shoulder region was observed in the survival curve of the cells after N-ion irradiation. Ratios of D₀ values before and after a 6-hour incubation in plateau phase were 1·1 and 1·8 for N-ion irradiation and γ-ray irradiation, respectively. The results show that recovery after irradiation with high-LET radiation is slow and much less than after low-LET irradiation.

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Differential Recovery from Potentially Lethal Damage in Normal Human Lung Fibroblasts after Irradiation with ⁶⁰Co γ-rays and Accelerated N-ion Beam

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Differential Recovery from Potentially Lethal Damage in Normal Human Lung Fibroblasts after Irradiation with 60Co γ-rays and Accelerated N-ion Beam

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Differential Recovery from Potentially Lethal Damage in Normal Human Lung Fibroblasts after Irradiation with ⁶⁰Co γ-rays and Accelerated N-ion Beam