Efficacy of Different DTPA Treatment Schedules for Removal of ²³⁴Th from Simulated Wounds in Rats

Summary

The translocation of ²³⁴Th from a simulated wound site and the efficacy of DTPA administration, as a function of the thorium compound injected as well as the DTPA treatment schedule, have been investigated in rats. Much more ²³⁴Th injected as citrate was translocated from the injection site than after administration as nitrate, whereas the distribution pattern of ²³⁴Th translocated to the various tissues was nearly identical for both ²³⁴Th compounds. Combined local and systematic treatment with DTPA was equally or more effective than each of the treatments alone in reducing the retention of ²³⁴Th at the injection site and in the organs.

• thorium
• contaminated wounds
• DTPA treatment
• rat