Mitotic Inhibition of ICR 2A Frog Cells Exposed to 265–313 nm Monochromatic Ultraviolet Wavelengths and Photoreactivating Light

Summary

Exposure of ICR 2A frog cells to 265, 289, 302 or 313 nm U.V. radiation caused a decrease in the MI of the irradiated cells in a fluence-dependent fashion. Treatment of cells with PRL immediately after U.V.-irradiation resulted in a smaller decrease in the MI, demonstrating that pyrimidine dimers played a role in the mitotic inhibition induced by these U.V. wavelengths. The effect of PRL on 313 nm-irradiated cells was much smaller than for the other wavelengths tested, indicating that non-dimer photoproducts were of importance in the mitotic inhibition induced by this U.V. wavelength.

• mitotic inhibition
• ultraviolet radiation
• photoreactivation
• frog cells