Oral Administration of Liposome-entrapped Cysteamine and the Distribution Pattern in Blood, Liver and Spleen

D. Jaskierowicz Division de Radiobiologie et de Radioprotection, Centre de Recherche du Service de Santé des Armées, 1 bis rue du Lieutenant Raoul-Batany, 92141, Clamart, France

F. Genissel Division de Radiobiologie et de Radioprotection, Centre de Recherche du Service de Santé des Armées, 1 bis rue du Lieutenant Raoul-Batany, 92141, Clamart, France

V. Roman Division de Radiobiologie et de Radioprotection, Centre de Recherche du Service de Santé des Armées, 1 bis rue du Lieutenant Raoul-Batany, 92141, Clamart, France

F. Berleur Division de Radiobiologie et de Radioprotection, Centre de Recherche du Service de Santé des Armées, 1 bis rue du Lieutenant Raoul-Batany, 92141, Clamart, France

M. Fatome Division de Radiobiologie et de Radioprotection, Centre de Recherche du Service de Santé des Armées, 1 bis rue du Lieutenant Raoul-Batany, 92141, Clamart, France

Summary

Oral administration of liposome-entrapped cysteamine induces an increase in the concentration of exogenous sulphur compounds in blood (plasma), liver and spleen. Among those sulphur compounds, an important amount of plasma thiols can be related to a protection of cysteamine in the digestive tract. This can account for the radioprotective effect of a liposomal-cysteamine suspension in rodents, and clearly demonstrates the interest of such a preparation in radioprotection.

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