Radiobiological Studies of Human Hybrid Cells (Skin Fibroblasts × HeLa) and Their Tumourigenic Segregants

J.L. Redpath Division of Radiation Oncology, Department of Radiological Sciences, California College of Medicine, University of California—Irvine, Irvine, California, 92717, U.S.A.

C. Sun Department of Microbiology and Molecular Genetics, California College of Medicine, University of California—Irvine, Irvine, California, 92717, U.S.A.

M. Colman Division of Radiation Oncology, Department of Radiological Sciences, California College of Medicine, University of California—Irvine, Irvine, California, 92717, U.S.A.

E.J. Stanbridge Department of Microbiology and Molecular Genetics, California College of Medicine, University of California—Irvine, Irvine, California, 92717, U.S.A.

Summary

Data are presented on the survival characteristics following γ-irradiation of a human hybrid cell line (skin fibroblasts × HeLa), and its tumourigenic segregant, which indicate that transition from the non-tumourigenic to the tumourigenic state is associated with a decrease in the ability to accumulate and repair sublethal damage. Previous studies have demonstrated that this transition to the tumourigenic state is also associated with loss of specific chromosomes (one copy each of chromosomes 11 and 14). It is suggested that this loss of chromosomes may account for the change in radiosensitivity.

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Radiobiological Studies of Human Hybrid Cells (Skin Fibroblasts × HeLa) and Their Tumourigenic Segregants

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Radiobiological Studies of Human Hybrid Cells (Skin Fibroblasts × HeLa) and Their Tumourigenic Segregants

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