Electrolytic Reduction of Nitroheterocyclic Drugs Leads to Biologically Important Damage in DNA

M.V.M. Lafleur Physics Laboratory of the Vrije Universiteit, Department of Biophysics, de Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands

A. Zahoor Chemotherapy Research Unit, Department of Paramedical Science, North East London Polytechnic, Romford Road, London, E15 4LZ, U.K.

R.C. Knight Physics Laboratory of the Vrije Universiteit, Department of Biophysics, de Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands

E.J. Pluijmackers-Westmijze Chemotherapy Research Unit, Department of Paramedical Science, North East London Polytechnic, Romford Road, London, E15 4LZ, U.K.

H. Loman Physics Laboratory of the Vrije Universiteit, Department of Biophysics, de Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands

D.I. Edwards Chemotherapy Research Unit, Department of Paramedical Science, North East London Polytechnic, Romford Road, London, E15 4LZ, U.K.

Summary

The effect of electrolytic reduction of nitroimidazole drugs on biologically active DNA was studied. The results show that reduction of the drugs in the presence of DNA affects inactivation for both double-stranded (RF) and single-stranded ϕX174 DNA. However, stable reduction products did not make a significant contribution to the lethal damage in DNA. This suggests that probably a short-lived intermediate of reduction of nitro-compounds is responsible for damage to DNA.

Keywords

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Electrolytic Reduction of Nitroheterocyclic Drugs Leads to Biologically Important Damage in DNA

Information for

Open access

Opportunities

Help and information

Electrolytic Reduction of Nitroheterocyclic Drugs Leads to Biologically Important Damage in DNA

Summary

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature