Effects of Local Hyperthermia on the Motor Function of the Rat Sciatic Nerve

J. Wondergem Department of Radiotherapy, University of Amsterdam, Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

J. Haveman Department of Radiotherapy, University of Amsterdam, Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

V. Rusman Department of Radiotherapy, University of Amsterdam, Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

P. Sminia Department of Radiotherapy, University of Amsterdam, Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

J.D.P. Van Dijk Department of Radiotherapy, University of Amsterdam, Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

Summary

The effect of local heat treatment of the sciatic nerve was assessed using the toe-spreading test, which mainly assesses the motor function of the sciatic nerve. A 5 mm long segment of the nerve was heated at temperatures from 42·0 to 45·0°C in vivo using a brass thermode. Hyperthermia led to a decrease in spreading of the toes. Recovery from functional loss took place in all cases, and this recovery was completed in 4 weeks. A 50 per cent functional loss in 50 per cent of the treated animals was observed after 58, 32 and 12 min of heating at 43·0, 44·0 and 45·0°C respectively.

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Effects of Local Hyperthermia on the Motor Function of the Rat Sciatic Nerve

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