Raf Involvement in the Simultaneous Genetic Transfer of the Radioresistant and Transforming Phenotypes

Kathleen F. Pirollo Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, U.S.A.

Rosa Garner Environment Epidemiology Branch, National Cancer Institute, Bethesda, MD, 20205, U.S.A.

Song Yang Yuan Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, U.S.A.

Li Li Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, U.S.A.

William A. Blattner Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, U.S.A.

Esther H. Chang Environment Epidemiology Branch, National Cancer Institute, Bethesda, MD, 20205, U.S.A.

Summary

We examined a human Alu⁺ mouse tertiary transformant derived from a noncancerous skin fibroblast cell line which exhibits the unique characteristic of being resistant to the killing effects of ionizing radiation. This transformed cell line was found to contain activated human c-raf-1, and demonstrated an increased level of radioresistance indicating the simultaneous transfer of both the transforming and radiation-resistant phenyotypes. We have also found a relationship between the presence of activated oncogenes, specifically those with serine/threonine kinase activity and the radioresistant phenotype.

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Raf Involvement in the Simultaneous Genetic Transfer of the Radioresistant and Transforming Phenotypes

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Raf Involvement in the Simultaneous Genetic Transfer of the Radioresistant and Transforming Phenotypes

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