Behaviour of Spherical and Irregular (U,Pu)O₂ Particles after Inhalation or Intratracheal Instillation in Rat Lung and during in Vitro Culture with Bovine Alveolar Macrophages

H.L. Müller Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Postfach 3640, D-7500, Karlsruhe 1, F.R. Germany

E. Drosselmeyer Commission of the European Communities, Joint Research Centre, European Institute for Transuranium Elements, Postfach 2340, D-7500, Karlsruhe 1, F.R. Germany

G. Hotz Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Postfach 3640, D-7500, Karlsruhe 1, F.R. Germany

A. Seidel Commission of the European Communities, Joint Research Centre, European Institute for Transuranium Elements, Postfach 2340, D-7500, Karlsruhe 1, F.R. Germany

H. Thiele Kernforschungszentrum Karlsruhe, Institut für Genetik und Toxikologie, Postfach 3640, D-7500, Karlsruhe 1, F.R. Germany

S. Pickering Commission of the European Communities, Joint Research Centre, European Institute for Transuranium Elements, Postfach 2340, D-7500, Karlsruhe 1, F.R. Germany

Summary

Spherical and irregularly shaped mixed (U,Pu) oxide particles were administered to rats by inhalation and by intratracheal instillation. The lung retention of the particles was independent of particle shape and of the route of administration. Only a small percentage of the administered radioactivity was found in other organs. Detailed electron microscopic studies showed particles within membrane-enclosed vacuoles as well as lying free in the cytoplasm.

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Behaviour of Spherical and Irregular (U,Pu)O₂ Particles after Inhalation or Intratracheal Instillation in Rat Lung and during in Vitro Culture with Bovine Alveolar Macrophages

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Behaviour of Spherical and Irregular (U,Pu)O2 Particles after Inhalation or Intratracheal Instillation in Rat Lung and during in Vitro Culture with Bovine Alveolar Macrophages

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Behaviour of Spherical and Irregular (U,Pu)O₂ Particles after Inhalation or Intratracheal Instillation in Rat Lung and during in Vitro Culture with Bovine Alveolar Macrophages