Inhibition of DNA Replication by Ionizing Radiation is Mediated by a Trans-acting Factor

J.R. Lamb MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, BN1 9RR, UK

C. Petit-Frère Department of Biophysics, University of Rochester School of Medicine, Rochester, NY, 14650, U.S.A.

B.C. Broughton MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, BN1 9RR, UK

A.R. Lehmann Department of Biophysics, University of Rochester School of Medicine, Rochester, NY, 14650, U.S.A.

M.H.L. Green MRC Cell Mutation Unit, Sussex University, Falmer, Brighton, BN1 9RR, UK

Summary

Gamma irradiation of a human cell line containing an extrachromosomal plasmid results in inhibition of the replication of both genomic and plasmid DNA. This inhibition is observed at doses of radiation which produce an insignificant amount of damage in the plasmid DNA molecules. These results indicate that radiation-induced inhibition of DNA replication is mediated by a trans-acting factor.

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Inhibition of DNA Replication by Ionizing Radiation is Mediated by a Trans-acting Factor

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