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Abstract
A total of 43 individuals were included in a study of genetic and environmental factors associated with cardiovascular disease; seven subjects (16%) were diagnosed with the metabolic syndrome. A statistically significant association was observed between the E2 allele of the apolipoprotein E (Apo E) polymorphism and an increasing number of metabolic syndrome features (p = 0.03). Clinical and biochemical abnormalities identified could be ascribed to the combined effects of unfavorable genotypes and environmental factors known to interact with the Apo E gene. Excessive alcohol intake, high-calorie diets and smoking should be restricted in individuals with the Apo E2 and/or E4 alleles, which are associated with a significantly increased risk of cardiovascular disease.
Acknowledgements
The study was supported by Winetech, the Technology for Human Resources and Industry Program (THRIP) and the Harry and Doris Crossley Foundation. Lujane Nutt is acknowledged for research assistance.
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