9
Views
0
CrossRef citations to date
0
Altmetric
Original Article

Genetic factors in alcohol use—a genetic epidemiological perspective

Pages 375-384 | Published online: 12 Jul 2009
 

Abstract

The purpose of this paper is to put a genetic epidemiological perspective on the role of genetic factors involved in the susceptibility and expression of alcohol use. The consequences of familial aggregation in a trait is explained, and the evidence for familial aggregation in alcoholism is viewed critically. Methods for making inference about unmeasured genetic factors from family-based studies of twins, adoptees, etc. are examined. The meaning and limitations of “heritability” are explained. A summary of the literature regarding the possible role of genetic factors on several aspects of alcohol use, including alcohol metabolism, is presented. Some of the evidence for measured genetic factors related to alcoholism and alcohol use is examined. The basic requirements for justifying genetic screening for an adult onset condition, such as alcoholism, are outlined. It is concluded that, although behavioural geneticists have tended to overstate the case for a genetic aetiology, it may only be a matter of time before one or more genetic loci, which in some part determine susceptibility to problem drinking and alcohol abuse, are identified. Genetic screening programmes, however, are unlikely to be justified, especially given the lack of proven prevention strategies.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.